ADVI Perspectives: IRA Implementation and “Government Negotiation”

Inflation Reduction Act Federal And State Policy

Lindsay Bealor Greenleaf, JD, MBA
September 15, 2023

President Biden’s announcement on the first ten drugs targeted for “government negotiation” under the Inflation Reduction Act (IRA) is set to shake up the pharmaceutical landscape.

ADVI expert Lindsay Bealor Greenleaf, vice president and head of policy, shared insights on why this is one of the biggest key policy reforms of the moment.

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Hear more from Lindsay on what’s to come for the IRA and provide an in-depth analysis of the highly anticipated government negotiation.

Key Policy Reform and Impacts to Consider for 2023 / 2024

ADVI Health explores key reforms and market trends related to the IRA.

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Stay ahead of the curve. Get in touch today to gain expert insights into the IRA and the evolving healthcare landscape.


Lindsay Bealor Greenleaf, JD, MBA
Senior Vice President, Market Access and Policy Strategy

CEO insights

Real analysis from people who’ve been there

Cell and Gene Precision Medicine State Policy

The 2026 Rare Disease Reality

Orphan drugs now represent approximately 20 percent of total prescription spend, and over 52 percent of the cell and gene …

Marc Samuels, JD, MPH
February 26, 2026

AI in the Patient Care Paradigm: Examining Regulatory Challenges to Clinical Adoption  

Artificial intelligence could transform clinical care, but regulatory hurdles slow adoption. Ensuring healthcare AI has adequate policy safeguards is paramount …

Marc Samuels, JD, MPH
December 30, 2025

Precision Medicine

2026 Life Sciences Forecast: AI, Next-Gen Cell & Gene Therapy, and Policy Disruption

In 2026, we expect the healthcare landscape to be defined by technology breakthroughs, market access disruption, and profound policy changes. …

Marc Samuels, JD, MPH
December 16, 2025

Inflation Reduction Act

What HEOR Information Does CMS Need for Drug Price Negotiations Under the IRA?

As the Inflation Reduction Act (IRA) reshapes drug pricing policy in the United States, the Centers for Medicare and Medicaid (CMS) …

December 1, 2025

Cell and Gene

Delivering on CAR T-cell Therapy’s Promise: Policy Solutions for the Next Era of Cancer Care

CAR T-cell therapy offers a groundbreaking treatment option for patients with relapsed or refractory hematologic malignancies, yet access remains severely …

Alicia Silver, MPP
November 21, 2025

Inflation Reduction Act

Real-World Effectiveness vs Clinical Trial Efficacy in Medicare

The Inflation Reduction Act (IRA) has ushered in a new era of drug pricing negotiations in the US. For the …

October 1, 2025

Inflation Reduction Act Pharmaceuticals and Biotech

Why is Medicare Data Central to IRA Negotiations?

The Inflation Reduction Act (IRA), passed in 2022, has transformed the way drug pricing will be managed in the United …

September 10, 2025

Rare Disease

The Unintended Consequences of Drug Pricing Policies on Orphan Drug Development

Rare diseases impact nearly 1 in 10 people in the US and are largely untreated, with 95 percent lacking FDA-approved …

June 23, 2025

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